The rabbit monoclonal antibody R19M specifically binds to the scFv region of a CD19-specific mouse monoclonal antibody (mAb, clone FMC63). CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells. The scFv region of FMC63 has been used to develop CD19-specific chimeric antigen receptor (CAR) T cells utilized in clinical trials.
|Immunogen||scFv region of a CD19-specific mouse mAb clone FMC63
|Storage buffer||Aqueous buffered solution containing protein stabilizer and ≤0.03% sodium azide
Preparation and Storage
Store undiluted at 4°C. Do not freeze.
The monoclonal antibody was purified by Protein A.
- Since applications vary, each investigator should titrate the reagent to obtain optimal results.
- Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.