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CAR Expression Detection


Evaluating CAR expression is an essential step in production of CAR-T cells. This is often done by flow cytometry by using protein L, anti-Fab antibody, target antigen or anti-idiotype antibody (anti-ID Ab) Among these common choices, anti-ID Ab is widely considered to be the best, because it offers high specificity and minimal background staining. An anti-ID Ab, mouse mab 136.20.1 (B Jena, et al., PLoS One, 2013), has been used in anti-CD19 CAR detection extensively by most top labs and in pre-clinical and clinical studies.

Cytoart’s Unique CAR-driven

Antibody Platform

Cytoart’s antibody development platform focuses on targeting the scFV region on CAR- T cells. scFV target detection is a valuable tool Cytoart implements in the development of antibodies for CAR T-cell detection reagents. Using scFV for target detection for CAR T-cell therapy offers several benefits:

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