In vivo CAR Engineering
Empowering the Next Generation of Cell Therapy with VHH Nanobody Solutions
- VHHs (Nanobodies) are compact, ultra-stable antigen-binding domains that offer superior tissue penetration and modularity for complex therapeutic designs.VHHs can serve as both high-affinity CAR constructs and precision targeting heads to reprogram T cells in invivo CAR engineering.
- We leverage cell-based screening to ensure VHHs recognize target proteins in their native conformation with pM-level binding potency. Our antibodies are rigorously validated for high specificity with negligible non-specific binding, ensuring a superior safety profile for clinical translation.
Precision CAR-Monitoring
High-Sensitive Anti-ID Ab for PK/PD and ADA Assessment
- CytoArt is the first commercial producer of anti-idiotype antibody for CAR-T detection. We cover 6 FDA-approved CAR-T targets worldwide.
- Our product portfolio enables robust CAR molecule tracking (PK/PD) and highly sensitive detection of anti-drug antibodies (ADA) across diverse technology platforms, including Flow Cytometry, ELISA and MSD.
- Data Integrity – Provide reproducible, regulatory-grade evidence to support clinical decision-making.
Our Technology Platform Excellence
Specialized Antibody Solutions with Guaranteed Quality
CytoArt boasts years of technical expertise with extensive experience in antibody discovery and production. Powered by a proprietary platform, a specialized team, and over 8 years of focus on anti-idiotypic antibodies, we enable rapid generation of high-quality antibodies (including VHHs)—delivering monoclonal antibodies in as few as 20 weeks.
Solutions for NHP Models
Rapid Assay Optimization & Technical Troubleshooting
Leu16-scFv anti-CD20 CAR, effective in both human and non-human primate (NHP) models, has become a widely adopted model for evaluating in vivo CAR-T delivery and function in preclinical animal studies.
To address the challenge of non-specific binding in monkey blood, we have optimized our antibody to significantly reduce background noise and ensure reliable assay results.